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Sequence-based sparse optimization methods for long-term loop closure detection in visual SLAM

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Abstract

Loop closure detection is one of the most important module in Simultaneously Localization and Mapping (SLAM) because it enables to find the global topology among different places. A loop closure is detected when the current place is recognized to match the previous visited places. When the SLAM is executed throughout a long-term period, there will be additional challenges for the loop closure detection. The illumination, weather, and vegetation conditions can often change significantly during the life-long SLAM, resulting in the critical strong perceptual aliasing and appearance variation problems in loop closure detection. In order to address this problem, we propose a new Robust Multimodal Sequence-based (ROMS) method for robust loop closure detection in long-term visual SLAM. A sequence of images is used as the representation of places in our ROMS method, where each image in the sequence is encoded by multiple feature modalites so that different places can be recognized discriminatively. We formulate the robust place recognition problem as a convex optimization problem with structured sparsity regularization due to the fact that only a small set of template places can match the query place. In addition, we also develop a new algorithm to solve the formulated optimization problem efficiently, which guarantees to converge to the global optima theoretically. Our ROMS method is evaluated through extensive experiments on three large-scale benchmark datasets, which record scenes ranging from different times of the day, months, and seasons. Experimental results demonstrate that our ROMS method outperforms the existing loop closure detection methods in long-term SLAM, and achieves the state-of-the-art performance.


Guest Editorial: WWWJ Special Issue of the 17th International Conference on Web Information Systems Engineering (WISE 2016)

Rectifying resistance-switching behaviour of Ag/SBTO/STMO/ $$\hbox {p}^{+}$$ p + -Si heterostructure films

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Abstract

The \(\hbox {Sr}_{0.88}\hbox {Bi}_{0.12}\hbox {TiO}_{3}/\hbox {SrTi}_{0.92}\hbox {Mg}_{0.08}\hbox {O}_{3}\) (SBTO/STMO) heterostructure films were prepared on \(\hbox {p}^{+}\hbox {-Si}\) substrates by sol–gel spin-coating technique, and the films had good crystallinity and uniform grain distribution. The heterostructure films with a structure of Ag/SBTO/STMO/\(\hbox {p}^{+}\hbox {-Si}\) exhibited a bipolar, remarkable resistance-switching characteristic, and \(R_{\mathrm{HRS}}/R_{\mathrm{LRS}}\,\,{\sim }10^{4}\). More importantly, the heterostructure films showed rectifying characteristic in the low resistance state (LRS), and the rectification ratio can reach \(10^{2 }\) at \(\pm 1\hbox { V}\). The dominant resistive-switching conduction mechanism of high resistance state (HRS) was Ohmic behaviour, and the LRS changed to space charge-limited current (SCLC).

Man-machine dialogue system optimization based on cloud computing

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Abstract

This paper studies the optimization and implementation of human-machine dialog system based on cloud computing technology. Firstly, the coarse-perceived hash generation based on the formant frequency is studied, and the detail-aware hash generation based on the energy difference in the time domain is studied. Then, the combination of coarse-perceived hash and detail-aware hash is elaborated. Secondly, the algorithm is tested and emulated. The algorithm matches the coarse-perceived hash sequence with fewer bits, and returns the voice number with similar rough features to the index voice after matching successfully, and matches the detail-aware hash sequence of the corresponding number voice. Then, the exact match of the result is gotten. Finally, it is concluded that the algorithm in this paper can effectively recognize the human voice.

Transcriptome sequencing analysis of two different genotypes of Asian pear reveals potential drought stress genes

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Abstract

‘Huangguan’ (HG) and ‘Whangkeumbae’ (HK) pears are two important Asian pear cultivars in China and South Korea, respectively. In practical production, ‘Huangguan’ pear is a drought-tolerant genotype while ‘Whangkeumbae’ pear is drought-sensitive. To uncover the mechanisms underlying pear tree tolerance to drought stress, a comprehensive transcriptome analysis was performed in this study. The results revealed a total of 1185 and 1667 differently expressed genes (DEGs) between control and treated plants of HG and HK pear, respectively. KEGG pathways enrichment analysis revealed that the DEGs were involved in the metabolism and signal transduction of various phytohormones. In HG, the DEGs annotated as ABA, gibberellic acid (GA), and salicylic acid (SA) were all upregulated, while those DEGs annotated as jasmonic acid (JA) were upregulated or downregulated. In HK, the DEGs annotated as ABA and JA were both upregulated or downregulated, but there were no DEGs annotated as GA and SA. In addition, there were 743 DEGs expressed in HG, but not in HK. Among them, there were 288 DEGs whose absolute values of log2(fold-change ratio) were greater than 2. Eight of the 288 DEGs were selected randomly for validating the reproducibility and accuracy of the transcriptome RNA-Seq data by using quantitative-PCR. Our results will be helpful for breeding drought-tolerant pear cultivars.

Adsorption of helical and saddle-shaped oligothiophenes on solid surface

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Abstract

The arrangement of oligothiophenes is essential for understanding the relationship between structure and properties particularly in the organic electronic field. The self-assembly behaviors of helical (TMS)2-[7]helicene (T1), naphthalene-cored double (TMS)2-[7]helicene (T2), and saddle-shaped cyclooctatetrathiophene (T3), its derivative α,α,α,α-tetraphenyl-cyclooctatetrathiophene (T4) on solid surface are firstly investigated by using a combination of scanning tunneling microscopy (STM) and density functional theory (DFT) calculation. 1,3,5-Tris(10-carboxydecyloxy)-benzene (TCDB) is selected to build flexible host networks to immobilize these oligothiophenes in order to capture their molecular adsorption images successfully. The observed monodisperse or polydisperse filling and long-range alignment of oligothiophenes are described based on the non-covalent interactions and commensurate structure between olihothiophene and cavity. We speculate that those molecularly defined alignments could lead to significantly understanding the application of such ordered monolayer in organic electronic devices.

A novel JSON based regular expression language for pattern matching in the internet of things

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Abstract

The Internet of Things work by constantly sensing the physical properties in the vicinity of the user such as ambient light, sounds, motion and temperature. These sensors produce huge volumes of data that has to be efficiently sifted for relevant events required triggering certain actions. In addition, filtering has to be performed to ensure that privacy-sensitive confidential data is not leaked. Efficient and expressive pattern matching is thus a key enabling technology for the full realization of ambient and humanized computing. The bulk of research in this area has focused on the use of specialized hardware and reducing of the memory footprint. Unfortunately, there has been limited work if any on optimizing the core elements of pattern matching- the regular expression language and the compilation process that is responsible for converting patterns into internal data structures. The importance of writing good REs so that on compilation they do not lead to unrealizable data structures is relatively less understood. In the proposed research, we empirically compare different RE processing engines and practically demonstrate that the compilation phase is highly memory intensive and time-consuming as compared to the matching phase -and hence is worth exploring for new techniques and optimizations. As a second important contribution, we propose a novel technique for defining regular expressions by utilizing JavaScript Object Notation. Our evaluation with carefully created patterns shows that the performance of the proposed technique is at par with competing approaches. It is also less ambiguous, extensible, more expressive and much appropriate for defining large and complex patterns.

Analysis of lipid adsorption on nanoparticles by nanoflow liquid chromatography-tandem mass spectrometry

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Abstract

Nanoparticles (NPs) tend to adsorb matrix molecules like proteins and lipids incubated with biological fluids, forming a biological corona. While the formation and functions of protein corona have been studied extensively, little attention has been paid to lipid adsorption on NPs. However, lipids are also abundantly present in biological fluids and play important roles in processes like cell signaling and angiogenesis. Therefore, in this study, we established the analytical procedure for study of lipid adsorption on three different types of NPs in two matrices: human serum and heavy cream, using nanoflow liquid chromatography-mass spectrometry (nanoflowLC-MS). Serum was chosen to represent the common environment the NPs would be present once entering human body, and heavy cream was the representative food matrix NPs may be added to improve the color or taste. Steps of liquid-liquid extraction were established and optimized to achieve maximum recovery of the adsorbed, standard lipids from the NPs. Then, the LC-MS/MS method was developed to attain base-line separation of the standard lipids that represent the major lipid classes. At last, the lipid adsorption profiles of the three NPs were compared. We found that the lipid adsorption profile on the same type of NP was significantly different between the two matrices. The established method will help us investigate lipid adsorption on additional NPs and reveal how it could be affected by the physiochemical properties of NPs and the presence of proteins and other components in the biological matrix.


Effects of hydrogel injection on borderzone contractility post-myocardial infarction

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Abstract

Injectable hydrogels are a potential therapy for mitigating adverse left ventricular (LV) remodeling after myocardial infarction (MI). Previous studies using magnetic resonance imaging (MRI) have shown that hydrogel treatment improves systolic strain in the borderzone (BZ) region surrounding the infarct. However, the corresponding contractile properties of the BZ myocardium are still unknown. The goal of the current study was to quantify the in vivo contractile properties of the BZ myocardium post-MI in an ovine model treated with an injectable hydrogel. Contractile properties were determined 8 weeks following posterolateral MI by minimizing the difference between in vivo strains and volume calculated from MRI and finite element model predicted strains and volume. This was accomplished by using a combination of MRI, catheterization, finite element modeling, and numerical optimization. Results show contractility in the BZ of animals treated with hydrogel injection was significantly higher than untreated controls. End-systolic (ES) fiber stress was also greatly reduced in the BZ of treated animals. The passive stiffness of the treated infarct region was found to be greater than the untreated control. Additionally, the wall thickness in the infarct and BZ regions was found to be significantly higher in the treated animals. Treatment with hydrogel injection significantly improved BZ function and reduced LV remodeling, via altered MI properties. These changes are linked to a reduction in the ES fiber stress in the BZ myocardium surrounding the infarct. The current results imply that injectable hydrogels could be a viable therapy for maintaining LV function post-MI.

High-Tech Acupuncture for Prevention of Lifestyle Diseases—A Sino-Austrian Cooperation Research Protocol on Heart Rate Variability

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Abstract

Background

Acupuncture can not only be used for well-known diseases, but also for so-called modern lifestyle-related diseases. Using innovative methods like e.g. new analyses of heart rate variability (HRV), it is also possible to investigate diseases like burnout syndrome, ie., qi deficiency in Chinese medicine (CM).

Objective

The main object of this research protocol is to perform research on the relationship of burnout syndrome and heart rate (HR) and HRV.

Methods

A total of 175 patients with burnout syndrome (qi deficiency syndrome) in five groups and 35 healthy volunteers will be investigated. Based on random numbers generated by computer and concealed in opaque envelops, the patients will be assigned to four acupuncture groups using Zusanli (ST 36) acupuncture stimulation, Guanyuan (CV4) acupuncture stimulation, both points, and both points with Streitberger device respectively, and a moxibustion group using both points mentioned above, with 35 cases in each group. Altogether four different experiments are planned. Experiment 1 includes 70 subjects and is a comparison between a burnout group and a control group (healthy volunteers). The evaluation parameters are different scores and indices of HR and HRV. Experiment 2 includes 140 subjects and compares the efficacy of different acupuncture points. In experiment 3 (105 subjects), acupuncture and moxibustion should be compared to healthy volunteers. Experiment 4 (70 subjects) investigates the long-term therapeutic effects of acupuncture and moxibustion on the scores of qi deficiency and HR/HRV in qi deficiency patients. In both the acupuncture and moxibustion groups, a total of 10 treatments will be performed.

Conclusions

The joint research aims at the scientific evaluation of CM, mainly in the field of HRV. This parameter could be a very good indicator of the state of health and can be inflfluenced by different acupuncture methods, as shown in the past.

OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway

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Abstract

Background

Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority of cases. In order to explore a new therapy for CAU, the current study was performed to investigate the possible functioning of the Oncostatin M receptor (OSMR) gene in the autoimmunity of CAU via regulation of the JAK/STAT3 signaling pathway.

Methods

CAU skin tissues from 24 CAU patients and normal skin tissues from normal subjects were collected. Hematoxylin-eosin (HE) staining was conducted to count eosinophils, and immunohistochemistry was carried out to detect the positive rate of OSMR expression in two kinds of skin tissues. A total of 72 Kunming (KM) mice were selected, and 60 mice were used for establishing CAU models and later transfected with different plasmids. The expression of inflammatory factors was evaluated by enzyme-linked immunosorbent assays (ELISA). Expressions of janus kinase (JAK), signal transducer and activator of transcription 3 (STAT3), interferon-stimulated gene 15 (ISG15), CT10-regulated kinase (CRK), and interferon regulatory factor 9 (IRF9) were identified using Western blot assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Epithelial cell proliferation was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay, and cell cycle distribution and cell apoptosis were assessed using flow cytometry.

Results

The findings confirm that OSMR protein expression and histamine release rate are highly elevated in human CAU skin tissues, and the expression of the JAK/STAT3 signaling pathway-related genes (OSMR, JAK2, STAT3, ISG15, CRK and IRF9) was up-regulated. OSMR gene silencing in CAU mice significantly decreases the content of inflammatory factors (IL-1, IL-6, IFN-γ, and IgE), the number of eosinophils, and reduces the expression of the JAK/STAT3 signaling pathway related genes, and further enhances cell proliferation, promotes cell cycle entry and inhibits apoptosis of epithelial cells.

Conclusion

All aforementioned results indicate that OSMR gene silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU.

Polyphenylene sulfide microfiber membrane with superhydrophobicity and superoleophilicity for oil/water separation

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Abstract

To dispose the increasing oil pollution, tremendous effective ways have been proposed to deal with the oil/water mixture. In this study, polyphenylene sulfide (PPS) microfiber membrane was firstly employed as the substrate for separation. Polyethylene wax (PEW) powder and polytetrafluoroethylene (PTFE) ultrafine powder were simply and effectively introduced on the PPS membrane by employing one-step spray-coating method. The as-prepared membrane displayed excellent oil affinity and water-repellent behaviors. Significantly, the obtained membrane showed long-term stability under various extreme conditions such as strong acid, alkali, salt solutions and high temperature. Moreover, this membrane could maintain high oil flux (above 3500 L/m2 h) and separation efficiency (above 98%) even after 20 cycles of oil/water separation and isolate a wide range of oil/water mixture effectively. The fabrication of superhydrophobic and superoleophilic PPS microfiber membrane presented here can be easily scaled up on a large scale, which will provide attractive potential in practical oil/water separation.

Lacustrine fan delta deposition alongside intrabasinal structural highs in rift basins: an example from the Early Cretaceous Jiuquan Basin, Northwestern China

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Abstract

Development of fan deltas alongside intrabasinal structural highs has been overlooked compared to those forming on basin margins. However, these fan deltas may provide important clues regarding the tectonic and climatic controls on deposition during rift development. This paper documents fan delta deposition alongside an intrabasinal structural high within the Early Cretaceous Xiagou Formation of the Jiuquan Basin, China, using subsurface geological and geophysical data. Deposits observed in drill core support fan delta deposition occurring almost exclusively through subaerial and subaqueous gravity flows. Subsurface mapping reveals a consistent decrease in the areal extent of fan deltas from lowstand to highstand system tracts, suggesting that deposition alongside the structural high is sensitive to lake-level changes. The temporal and spatial distribution of the fan deltas display retrogradational stacking patterns, where fan deltas exhibit a decreasing lateral extent up-sequence until fan delta deposition terminated and was replaced by deposition of fine-grained lacustrine deposits. The retrogradational stacking patterns observed alongside the intrabasinal structural high are not observed in fan deltas along the basin margin in the lower parts of the Xiagou Formation. Subsidence profiles also show differential subsidence across the basin during the earliest stages of this formation, likely resulting from border fault movements. These data suggest that non-uniform stacking patterns in the lower parts of the Xiagou Formation reflect basin-scale tectonic movements as the dominant control on synrift deposition patterns. However, later stages of Xiagou Formation deposition were characterized by uniform subsidence across the basin, and uniform retrogradational stacking patterns for fan deltas alongside the intrabasinal structural high and border fault. These observations suggest that basin-scale tectonic movements played a relatively limited role in controlling sediment deposition, and imply a potential change to regional-scale processes affecting fan delta deposition during later synrift stages. Climate change is favored here as the region-scale control on the uniform retrogradational fan delta stacking patterns. This assertion is supported by pollen assemblages, isotope signatures, and organic geochemical analyses, which collectively suggest a change from a humid to semi-arid environment during later synrift stages. We suggest that variations in stacking patterns between different fan delta systems can provide insights into the basin- and regional-scale processes that control rift basin deposition.

Brazilin induces FOXO3A-dependent autophagic cell death by disturbing calcium homeostasis in osteosarcoma cells

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Abstract

Purpose

Osteosarcoma is a common primary malignant bone tumour, and its cure rate has stagnated over the past 25–30 years. Brazilin, a purified natural product from sappan wood (Caesalpinia sappan L.), has been proved to possess potent anti-cancer effects. In this study, we investigated the anti-cancer effect of brazilin on human osteosarcoma and elucidated the underlying mechanisms.

Methods

We exposed MG-63 cells to different concentrations of brazilin (5, 10 and 20 µM) for 24 h. Western blotting, immunocytofluorescence, luciferase reporter assays, and RT-PCR were used to evaluate whether brazilin activates FOXO family-dependent autophagy.

Results

Brazilin increased autophagic flux in the human osteosarcoma cell line MG-63, as evidenced by the upregulation of LC3-II and the downregulation of P62/SQSTM1. Moreover, the pharmacological or genetic blockade of autophagy decreased brazilin-induced cell death, indicating that brazilin triggered autophagic cell death in MG-63 cells. Specifically, brazilin induced FOXO3A(Ser7) phosphorylation, activated FOXO3A nuclear translocation and increased FOXO3A reporter activity, which contributed to the expression of autophagy-related genes and subsequently initiated autophagic cell death in MG-63 cells. Importantly, the increased expression and nuclear translocation of FOXO3A were tightly related to the disturbance of calcium homeostasis, which could be prevented by chelating intracellular calcium.

Conclusions

Taken together, these data demonstrate that brazilin induces osteosarcoma cell death by inducing excessive autophagy, which is mediated through the Ca2+-FOXO3A pathway. Our study provides a new anti-tumour mechanism for brazilin treatment in osteosarcoma patients.

Autophagy plays a protective role against apoptosis induced by toxicarioside N via the Akt/mTOR pathway in human gastric cancer SGC-7901 cells

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Abstract

Toxicarioside N (Tox N), a natural product extract from Antiaris toxicaria, has been reported to induce apoptosis in human gastric cancer cells. However, the mechanism and actual role of autophagy in Tox N-induced apoptosis of human gastric cancer cells remains poorly understood. In the current study, we demonstrated that Tox N could induce autophagy by inhibiting the Akt/mTOR signaling pathway in SGC-7901 cells. Moreover, we found that the inhibition of autophagy by 3-methyladenine, an autophagy inhibitor, enhanced Tox N-induced apoptotic cell death. However, the stimulation of autophagy by rapamycin, an autophagy activator, remarkably suppressed Tox N-induced apoptosis, suggesting that autophagy plays a protective role in Tox N-induced apoptosis. Thus, the results from this study suggested that Tox N combination with an autophagy inhibitor might be a promising strategy to enhance the anticancer activity of Tox N for the treatment of human gastric cancer.


Hierarchy and subsurface correlation of muddy baffles in lacustrine delta fronts: a case study in the X Oilfield, Subei Basin, China

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Abstract

Muddy baffles are one of the major geological factors controlling the underground fluid flow as well as the remaining oil distribution. This study used detailed drilling data from the E1f1 reservoir in the X Oilfield, Subei Basin, China, to investigate the hierarchical muddy baffles developed on lacustrine delta fronts and their precise cross-well correlation. According to the theories on allogenic and autogenic cycles as well as the genesis and scales of muddy baffles, five orders of muddy baffles were classified, which provided various degrees of difficulty when attempting interwell correlation. Under the guidance of a reliable stratigraphic model, the precise cross-well correlation of muddy baffles could be achieved and the key point of establishment of this stratigraphic model was to calculate foreset angles of hierarchical muddy baffles during deposition. During calculation, the relationships between sediment flow direction, higher-order strata dipping direction, well types and well trajectory direction should all be taken into consideration and some other angles (referred to here as θ1, θ2 and θ3) should also be measured. Such new methods of cross-well correlation for hierarchical muddy baffles could greatly reduce the uncertainties and multiple solutions, which in turn would be significant for efficient development and oil recovery enhancement in the reservoirs.

Lycorine inhibits glioblastoma multiforme growth through EGFR suppression

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Abstract

Background

Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers through some peripheral mechanism, in-depth mechanism studies of Lycotine’s anti-GBM effects still call for further exploration. Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in GBM. Targeting EGFR by small molecular inhibitors is a rational strategy for GBM treatment.

Methods

The molecular docking modeling and in vitro EGFR kinase activity system were employed to identify the potential inhibitory effects of Lycorine on EGFR. And the Biacore assay was used to confirm the direct binding status between Lycorine and the intracellular EGFR (696–1022) domain. In vitro assays were conducted to test the suppression of Lycorine on the biological behavior of GBM cells. By RNA interference, EGFR expression was reduced then cells underwent proliferation assay to investigate whether Lycorine’s inhibition on GBM cells was EGFR-dependent or not. RT-PCR and western blotting analysis were carried out to investigate the underlined molecular mechanism that Lycorine exerted on EGFR itself and EGFR signaling pathway. Three different xenograft models (an U251-luc intracranially orthotopic transplantation model, an EGFR stably knockdown U251 subcutaneous xenograft model and a patient-derived xenograft model) were performed to verify Lycorine’s therapeutic potential on GBM in vivo.

Results

We identified a novel small natural molecule Lycorine binding to the intracellular EGFR (696–1022) domain as an inhibitor of EGFR. Lycorine decreased GBM cell proliferation, migration and colony formation by inducing cell apoptosis in an EGFR-mediated manner. Furthermore, Lycorine inhibited the xenograft tumor growths in three animal models in vivo. Besides, Lycorine impaired the phosphorylation of EGFR, AKT, which were mechanistically associated with expression alteration of a series of cell survival and death regulators and metastasis-related MMP9 protein.

Conclusions

Our findings identify Lycorine directly interacts with EGFR and inhibits EGFR activation. The most significant result is that Lycorine displays satisfactory therapeutic effect in our patient-derived GBM tumor xenograft, thus supporting the conclusion that Lycorine may be considered as a promising candidate in clinical therapy for GBM.

Immobilization of Ag 3 PO 4 nanoparticles on chitosan fiber for photocatalytic degradation of methyl orange

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Abstract

Ag3PO4 and chitosan fiber (CF) composites were successfully fabricated using an in situ growth technique. The structure and properties of the obtained Ag3PO4/CF composites were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), energy dispersive spectroscopy, and UV–visible diffuse reflectance spectroscopy. SEM results suggested that the 50–500 nm Ag3PO4 particles grew on the CF surface into a spherical or dentate shape. Photocatalytic degradation of methyl orange (MO) solution was used as a typical reaction to evaluate the visible-light photocatalytic performance of the Ag3PO4/CF composites. The reaction results indicated that the Ag3PO4/CF composites-3 exhibited excellent photodegradation efficiency, with 93.8% removal of the MO solution. The effects of MO concentrations and cycling runs on the photocatalytic performance of the Ag3PO4/CF composites were evaluated as well.

Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China

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Abstract

Purpose

Lentinan is a polysaccharide extracted from Shiitake mushrooms that have been used to improve general health for thousands of years in Asia. Lentinan injection is a clinically approved drug in several countries in Asia. The purpose of this study is to review the structure, preclinical and clinical studies, and molecular mechanisms of lentinan. Most importantly, the clinical effectiveness of lentinan as an adjuvant therapeutic drug in treating patients with lung cancer in China during the past 12 years is analyzed statistically.

Methods

We carried out literature search of randomized controlled trials (RCTs) published from 2004 to 2016 based on CNKI (China National Knowledge Infrastructure), VIP (Chongqing VIP Chinese Scientific Journals Database) and Wanfang database, and 38 eligible RCTs of lentinan-associated lung cancer treatment were identified, containing 3,117 patients.

Results

The structure and function relationship and underlying molecular mechanism of lentinan as an immunostimulant has been summarized. The mean value of overall response rate in treating lung cancer was increased from 43.3% of chemotherapy alone to 56.9% of lentinan plus chemotherapy [p < 0.001, 95% confidence interval (CI) 0.102–0.170]. Compared with chemotherapy alone, lentinan plus chemotherapy showed more efficacy in treating lung cancer (pooled RR 0.79, 95% CI 0.74–0.85) and no statistical heterogeneity was found among studies (I2 = 11%).

Conclusion

Clinical data presented in the past 12 years shows that lentinan is effective not only in improving quality of life, but also in promoting the efficacy of chemotherapy during lung cancer treatment.

The growth and approximation for an analytic function represented by Laplace–Stieltjes transforms with generalized order converging in the half plane

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Abstract

By utilizing the concept of generalized order, we investigate the growth of Laplace–Stieltjes transform converging in the half plane and obtain one equivalence theorem concerning the generalized order of Laplace–Stieltjes transforms. Besides, we also study the problem on the approximation of this Laplace–Stieltjes transform and give some results about the generalized order, the error, and the coefficients of Laplace–Stieltjes transforms. Our results are extension and improvement of the previous theorems given by Luo and Kong, Singhal, and Srivastava.

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